Methyl Cycle Defects

*To make the search easier, press CTRL+F and punch in the key word, like "CBS" , or "Methyl" and hit Enter.


If you have allergies and inexplicable chemical sensitivities that make you sick,  you just might wanna test your genes.  And the first thing to look at is Methyl Cycle Abnormalities.  I had suspected those in me and the results did confirm it! So I'm eager to document and share my amateur research, trials, errors, and all. 

First off, I got a test-kit from 23&me company, which provides you with raw data on your genetic code.  After I got my results, I used a couple of helpful apps that found my abnormalities for me - Livewello and Genetic Genie.  Then, I started studying literature on the subject, which is quite a new trend in medicine, so a very,  very few, very, very expensive specialists can give you a very,.. well you know, consultation.  Thankfully,  there are studies available for you to explore on your own.  like THIS ONE, or THIS ONE.  I will be placing the multitude of references on my "Links" page. 

How do I understand what

 Methyl Cycle Abnormalities

are:

 Trying to explain is a good way to understand smth better. It took me three days to prepare a lecture for my loved ones, so they know what the heck I am getting involved with. Basically i boiled it down to this: there are genetic mutations that make metabolism of certain important chemicals not work properly, either causing toxic abundance or impairing shortage... Then i continued with each individual mutation, saying that CBS causes toxic abundance of sulfur-family chemicals... etc etc.. They seemed satisfied.

There was a bit of confusion  though, as far as Methylation Function itself and Methyl Cycle defects. I'll share my amateur conclusions on this one.   While there's a bunch of articles explaining Methylation as "functionally relevant changes to the genome that do NOT involve a change in the nucleotide sequence"  or " a process by which a gene's behavior is altered, but the gene itself isn't changed" those articles refer to a  different and a broader subject of Epigenetics. 

Epigenetics is studying  modifications, that are carried out through acetylation, methylation, ubiquitylation, phosphorylation and sumoylation. But in my opinion it's often getting confused with  "my" specific subject of Methylation Process itself being genetically impaired . 


 In Methyl Cycle Defects  you are  looking at Nutrigenomics,  a much more detailed picture,  and find the process of Methylation also being a "genetic code" of it's own. 

Epigenetics looks at Methylation as a kinda of a tool that carves out those non-gene-changing modifications. But in my case, I look at what happens if this tool is broken. I look at why my methylation does not do the job properly and find that the genetic code responsible for this tool is screwed up...

 In other words, my Methyl Cycle Single Nucleotide Sequences ARE changed, they are mutated.  So  once again, it seems clear, that in my body, the silencing or expressing of genes without "a change in nucleotide sequence" is carried out by a mutated, defective Methylation process, and THAT's what makes me sick .  

As far as expression or non-expression of Defective Methyl Cycle  genes themselves due do environmental changes, I am under the impression that it is not quite applicable to methylation, since if a certain gene is mutated there is no way you're gonna have the part of metabolism it is responsible for, work in any other way then the way it's programmed - crooked way, that is. How soon in your life you start having noticeable issues it's a different story, it seems that you need a little time for the parts with no mutations to start getting taxed and then you'll notice smth's wrong.. Also we're programmed to age, with each year  our rna replicates with a worse quality, so when the "good" parts wear down enough there's a chance you'll start feeling smth..

I do understand that having faulty genes makes you vulnerable to environmental and nutritional exposures, (like myself getting sick from this or that) because you don't have the right chemicals in your body to handle the exposures in a healthy way, so if the "expression" means feeling sick, then environment does promote it. I am trying to say though, whether you're feeling it, or not, the genes still work wrongly, just the way they're programmed, making the environment an issue. You're kinda of set with your genes for life, the only changes that are possible are malignant cell mutations. It sounds so hopeless, though, like you're stuck with it no matter what... Don't wanna be a total pessimist,  I'm already kinda happy and hopeful, that bypassing dysfunctional genes and "tricking" your system with help of supplements seems like an option! 

 The way I see  it currently, I'd compare "defective" methylation to horses driving a carriage, some of them are very sick and weak and others are strong and healthy. Even if the carriage is still going, it's going slower and slower because the sick horses can't keep up and make it hard for the healthy ones. When the sick horses collapse, the carriage stops, healthy horses might get injured or ill from stress, etc etc... So you need to strengthen and pamper the sick horses in any way you can, to ride your carriage as long as possible... Kinda..

Speaking of the lecture I prepared for my loved ones - it is turning out to be helpful over and over again,  since I'm using it as my reference in case i need to confirm smth.  My amateur research is a work in progress, but   Here's what I've come up with so far regarding the mutations I personally am confirmed having, and their "wrongs". 

LET'S START WITH THESE ONES:

CBS, BHMT, COMT.

CBS + 

(it over-produces)

Excess of:

Cystathionine Metabolites

Sulfur-y chemicals 

Ammonia

Lack of:  

Homocysteine amino-acid

BH4 cofactor

BHMT+

 (it under-produces)

Lack of: 

Homocysteine amino-acid

BH4 cofactor

 COMT +

(it under-produces)

Excess of:

Methyl Groups

 Spared somewhat:

Dopamine 

BH4 cofactor

Methyl toxicity is increased if: 

VDR taq (-)

Methyl toxicity  is decreased if:

 VDR taq (+)

VDRtaq+

I found this little formula really helpful, in my case it proved right. Most of the time

VDRbsm(++) = VDRtaq(--)

Lack of: 

Dopamine

 Vitamin D 

Methyl Donors 

More Methyl and Dopamine depletion if:  

COMT (-)

to be continued..